The role of thiamine as a resuscitator in patients with nonalcoholic medical and CNS disorders
Thiamine (vitamin B1), a water-soluble vitamin, is an essential factor in cellular metabolism
and fundamental cofactor in important biochemical cycles. Thiamine deficiency is a wellknown
cause of neurological and cardiologic disorders, especially in patients with alcohol
dependence. Recently, several researchers have studied the role of thiamine deficiency in
critically ill patients and the link between thiamine supplementation and changes in lactate
levels in septic shock patients. The role of thiamine in this group of patients is still unclear;
however, thiamine supplementation does not cause toxic side effects or increase morbidity
or mortality. In this review, we discuss the most common conditions associated with thiamine
deficiency and the limited literature available on thiamine supplementation in critically ill
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