The role of thiamine as a resuscitator in patients with nonalcoholic medical and CNS disorders

  • Mohamed Shehab-Eldin Department of Neurology at Texas Tech University Health Sciences Center in Lubbock, TX.

Abstract

Thiamine (vitamin B1), a water-soluble vitamin, is an essential factor in cellular metabolismand fundamental cofactor in important biochemical cycles. Thiamine deficiency is a wellknowncause of neurological and cardiologic disorders, especially in patients with alcoholdependence. Recently, several researchers have studied the role of thiamine deficiency incritically ill patients and the link between thiamine supplementation and changes in lactatelevels in septic shock patients. The role of thiamine in this group of patients is still unclear;however, thiamine supplementation does not cause toxic side effects or increase morbidityor mortality. In this review, we discuss the most common conditions associated with thiaminedeficiency and the limited literature available on thiamine supplementation in critically illpatients.

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References

Frank RA, Leeper FJ, Luisi BF. Structure, mechanism

and catalytic duality of thiamine-dependent enzymes. Cell

Mol Life Sci 2007 Apr; 64(7-8):892-905.

Manzanares W, Hardy G. Thiamine supplementation in the

critically ill. Curr Opin Clin Nutr Metab Care 2011 Nov;

(6):610-7.

DiNicolantonio JJ, Niazi AK, Lavie CJ, O’Keefe JH, Ventura

HO. Thiamine supplementation for the treatment of heart failure:

a review of the literature. Congest Heart Fail 2013

Jul-Aug; 19(4):214-22.

Gabrielli A, Caruso L, Stacpoole PW. Early recognition of

acute cardiovascular beriberi by interpretation of hemodynamics.

J Clin Anesth 2001 May; 13(3):230-8.

Singer M. Mitochondrial function in sepsis: acute phase versus

multiple organ failure. Crit Care Med 2007 Sep; 35(9

Suppl):S441-8.

Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H,

Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke

R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K,

Kleinpell RM, Angus DC, Deutschman CS, Machado FR,

Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R;

Surviving Sepsis Campaign Guidelines Committee including

The Pediatric Subgroup. Surviving Sepsis Campaign:

international guidelines for management of severe sepsis

and septic shock, 2012. Intensive Care Med 2013 Feb;

(2):165-228.

Trzeciak S, Dellinger RP, Chansky ME, Arnold RC, Schorr

C, Milcarek B, Hollenberg SM, Parrillo JE. Serum lactate as

a predictor of mortality in patients with infection. Intensive

Care Med 2007 Jun; 33(6):970-7.

Lee SM, An WS. New clinical criteria for septic shock:

serum lactate level as new emerging vital sign. J Thorac Dis.

Jul; 8(7):1388-90.

Suetrong B, Walley KR. Lactic Acidosis in Sepsis: It’s Not

All Anaerobic: Implications for Diagnosis and Management.

Chest 2016 Jan; 149(1):252-61.

Donnino MW, Carney E, Cocchi MN, Barbash I, Chase M,

Joyce N, Chou PP, Ngo L. Thiamine deficiency in critically

ill patients with sepsis. J Crit Care. 2010 Dec; 25(4):576-81.

Donnino MW, Andersen LW, Chase M, Berg KM, Tidswell

M, Giberson T, Wolfe R, Moskowitz A, Smithline H, Ngo

L, Cocchi MN; Center for Resuscitation Science Research

Group. Randomized, Double-Blind, Placebo-Controlled

Trial of Thiamine as a Metabolic Resuscitator in Septic

Shock: A Pilot Study. Crit Care Med 2016 Feb; 44(2):360-7.

Frontera JA. Metabolic encephalopathies in the critical care

unit. Continuum (Minneap Minn). 2012 Jun; 18(3):611-39.

Scalzo SJ, Bowden SC, Ambrose ML, Whelan G, Cook MJ.

Wernicke-Korsakoff syndrome not related to alcohol use: a

systematic review. J Neurol Neurosurg Psychiatry 2015 Dec;

(12):1362-8.

Kumar N. Neurologic complications of bariatric surgery.

Continuum (Minneap Minn). 2014 Jun; 20(3 Neurology of

Systemic Disease):580-97.

Galvin R, Bråthen G, Ivashynka A, Hillbom M, Tanasescu R,

Leone MA; EFNS. EFNS guidelines for diagnosis, therapy

and prevention of Wernicke encephalopathy. Eur J Neurol

Dec; 17(12):1408-18.

Staff NP, Windebank AJ. Peripheral neuropathy due to vitamin

deficiency, toxins, and medications. Continuum (Minneap

Minn). 2014 Oct;20(5 Peripheral Nervous System

Disorders):1293-306.

Hazell AS1. Astrocytes are a major target in thiamine deficiency

and Wernicke’s encephalopathy. Neurochem Int 2009

Jul-Aug; 55(1-3):129-35.

Sica DA. Loop diuretic therapy, thiamine balance, and

heart failure. Congest Heart Fail 2007 Jul-Aug; 13(4):

-7.

Jain A, Mehta R, Al-Ani M, Hill JA, Winchester DE. Determining

the Role of Thiamine Deficiency in Systolic Heart

Failure: A Meta-Analysis and Systematic Review. J Card

Fail 2015 Dec; 21(12):1000-7.

Published
2017-05-05
How to Cite
Shehab-Eldin, M. (2017). The role of thiamine as a resuscitator in patients with nonalcoholic medical and CNS disorders. The Southwest Respiratory and Critical Care Chronicles, 5(19), 11-15. https://doi.org/10.12746/swrccc.v5i19.398