Chronic thromboembolic pulmonary hypertension: a case-based discussion of current management and latest guidelines

Neha Sivaguru MD, Vaishnavi Sabesan MD, Patrick Kicker DO, Dan Schuller MD

ABSTRACT

Purpose of review: Frequently underdiagnosed, chronic thromboembolic pulmonary hypertension (CTEPH) is associated with high morbidity and mortality. We highlight recent advancements in evaluation and management.

Recent findings: This study focuses on a case-based management approach for CTEPH. It outlines the initial evaluation, treatment approach, and the importance of timely intervention. Although a surgical approach can potentially be curative, we discuss the role of medical management and balloon pulmonary angioplasty (BPA).

Summary: This review highlights the importance of early recognition, diagnostic evaluation, and current evidence-based multidisciplinary management of patients with CTEPH.

Keywords: Chronic thromboembolic pulmonary hypertension, pulmonary endarterectomy, balloon pulmonary angioplasty, riociguat.


Article citation: Sivaguru N, Sabesan V, Kicker P, Schuller D. Chronic thromboembolic pulmonary hypertension: A case-based discussion of current management and latest guideline. The Southwest Journal of Medicine 2025;13(56):30–36
From: Department of Internal Medicine, Texas Tech University Health Sciences Center, Texas Tech University Health Sciences Center El Paso – Transmountain, The Hospitals of Providence-Transmountain
Submitted: 5/21/2025
Accepted: 6/20/2025
Conflicts of interest: none
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