Chanokporn Puchongmart MD, Koravich Lorlowhakarn MD, Ben Thiravetyan MD, Panat Yanpiset MD, Thanaboon Yinadsawaphan MD, Narathorn Kulthamrongsri, MD, Mahmood Abdelnabi, MD, Natnicha Leelaviwat MD, Ankush Lahoti, MD
Background: Ventricular arrhythmias, including ventricular tachycardia and ventricular fibrillation, are well-known contributors to adverse outcomes in type 1 myocardial infarction, but their significance in type 2 myocardial infarction remains underexplored.
Objective: We investigated the incidence of ventricular arrhythmias and their association with clinical outcomes among patients with type 2 myocardial infarction.
Methods: This retrospective cohort study utilized the National Inpatient Sample (2017–2022) and included adults hospitalized for type 2 myocardial infarction. Ventricular arrhythmias were identified using ICD-10-CM codes. Multivariable models were adjusted for patients’ demographics and comorbidities and employed to identify predictive factors for in-hospital mortality, length of stay, and total hospital charges.
Results: A total of 2,016,430 patients were included, and 5.89% developed ventricular arrhythmias. Patients with ventricular arrhythmias were younger (69.5 vs. 70.6 years, p < 0.01), less female (33.4% vs. 47.9%, p < 0.01), and more frequently African American (20.1% vs 17.0%, p < 0.01). Ventricular arrhythmias were associated with significantly increased in-hospital mortality (19.3% vs. 9.2%, p < 0.01), prolonged hospital length of stay (7 vs 5 days), and higher total hospital charges ($99,437 vs. $60,297 p < 0.01). Adjusted multivariate models demonstrated ventricular arrhythmias as an independent predictor for in-hospital mortality (aOR 2.39, 95% CI 2.31–2.48), longer length of stay (β 2.83 days, 95% CI 2.66–3.00), and higher total hospital charges (cost ratio 1.60, 95% CI 1.57–1.63).
Conclusion: The incidence of ventricular arrhythmias is notable among hospitalized patients with type 2 myocardial infarction is associated with significantly worse clinical and economic outcomes.
Keywords: Type 2 myocardial infarction; ventricular tachycardia; ventricular fibrillation; mortality
Article citation: Puchongmart C, Lorlowhakarn K, Thiravetyan B, Yanpiset P, Yinadsawaphan T, Kulthamrongsri N, Abdelnabi M, Leelaviwat N, Lahoti A. Ventricular arrhythmias in type 2 myocardial infarction: Incidence and in-hospital outcomes: A national inpatient analysis (2017–2022). The Southwest Journal of Medicine. 2026;14(59):8–15
From: Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Tx (CP, BT, PY, NL, AL) Boston Medical Center Health System Boston, MA (KL) Department of Internal Medicine, John A Burns School of Medicine, Honolulu, HI (TY, NK) Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ (MA)
Conflicts of interest: none
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