Acute pancreatitis and diabetic ketoacidosis associated with compounded semaglutide

Abstract

This case describes a patient without a history of diabetes who, after three months of compounded semaglutide use, presented with acute pancreatitis complicated by diabetic ketoacidosis (DKA). The patient presented to the ED with nausea, vomiting and mild abdominal pain. She was found to be in high anion gap metabolic acidosis, hyperglycemic and with elevated lipase. The patient was treated for DKA, with resolution of her symptoms. She was ultimately discharged without insulin and advised to stop her semaglutide.

Keywords: Glucagon-Like Peptide 1, pancreatitis, Diabetic Ketoacidosis, hyperglycemia