Self-extubation in ICU patients

The incidence of unplanned extubations per 100 intubated patients, which includes both self-extubation and accidental extubation, ranges from 0.514.2 patients. In a retrospective study of 273 patients admitted to the ICU and requiring intubation, Singh reported a 12.4% incidence of self-extubation.1 When calculated per 100 intubation days, the incidence of unplanned extubation is 0.3-4.0 per 100 days. Selfextubation, defined as a deliberate action taken by the patient to remove the endotracheal tube, accounts for 68%-95% of all unplanned extubations.2 Accidental extubation refers to any non-deliberate action, such as coughing, tube manipulation, etc., taken by either medical personnel or the patient that results in removal of the endotracheal tube.2

Additional factors that correlate with a higher frequency of self-extubation include male gender (67%), sedation given on an "as needed" basis rather than as a continuous infusion, and a current history of smoking. 6Self-extubation is more common in surgical patients, burn patients, and older patients.In a retrospective study conducted by Tung, the average age of patients who self-extubated was 65.3 years. 7atients between ages 30-50 account for 47% of self-extubation episodes; 58.9% of episodes occur in surgical patients. 1Self-extubation also occurs more frequently in patients with certain conditions, such as chronic obstructive pulmonary disease, adult respiratory distress syndrome, or cardiac disease. 6This increased frequency could, however, simply reflect the longer intubation periods and weaning in these patient groups. 2

b. nurse related
Nursing care is an important factor that contributes to a patient's likelihood to self-extubate, and the attending nurse's absence from the bedside is the most important predictor.This is closely followed by decreased patient surveillance and a low nurse to patient ratio.The optimal ratio to decrease the incidence of self-extubation is probably one to one, and while this may not be feasible, patients with a high risk of self-extubation should be allocated more supervision. 3In addition, less experienced nurses are more likely to encounter self-extubation; staffing with registered nurses has significantly reduced the risk of selfextubation. 8It has been shown that patients under the care of an ICU nurse with >4 years of experience have a 2.6% lower incidence of self-extubations. 3e incidence of self-extubation is higher during the night shift (76%), which could reflect a higher risk for patient delirium at night or decreased patient surveillance. 5The effect of decreased patient surveillance on self-extubation is also demonstrated by the higher frequency of self-extubations occurring within the hour before and after shift changes, when patients are often monitored less.Self-extubation during shift changes between 7:00 am and 8:30 am and 7:00 pm and 8:30 pm accounted for almost 50% of the self-extubations in a tertiary care ICU over a one year period. 1

OutcOmes
Self-extubation has the potential to damage the larynx and cause severe airway complications due to removing the tube with the cuff still inflated.Hypotension, arrhythmias, bronchospasm, aspiration, and laryngeal bleeding or edema can also occur.In addition, up to 20% of patients have a difficult re-intubation following self-extubation. 2wever, self-extubation often occurs in patients who are ready for elective extubation within the next few hours.Patients who self-extubate within 72 hours of a planned extubation require re-intubation in only 14% of cases.Therefore, in the majority of patients who do not require re-intubation, self-extubation can actually decrease the length of intubation and weaning. 2,3,9e complications of self-extubation are seen most often in patients requiring re-intubation, which occurs within an hour of self-extubation in 85%-90% of cases. 2 Risk factors for re-intubation include a higher pre-extubation fraction of inspired oxygen (FiO 2 ), a lower ratio of arterial oxygen tension to inspired oxygen concentration (PaO 2 /FiO 2 ), assist/control ventilation mode, female gender, decreased mental status related to sedation or illness, organ dysfunction, infection, increased pulmonary secretions, tachycardia, temperature greater than 37.5°C, pH greater than 7.45, and poor pulmonary compliance. 2,3Only 45% of patients who self-extubate require re-intubation; however, these patients have a sevenfold higher ICU or hospital mortality rate compared to successfully self-extubated patients. 2,5In addition, patients who are re-intubated are more likely to have nosocomial ventilator-associated pneumonia. 2

PreventiOn
Physical restraints have been historically used to prevent self-extubation; however, according to Tung, restraint use is actually associated with selfextubation.He reported that 65% of patients who self-extubated were restrained either at the time of self-extubation or within 24 hours of self-extubation. 7estraints are often used with agitated or delirious patients, whose risk for self-extubation is already increased.A quality improvement initiative increased restraint use in agitated patients from 58% to 90% over four years and saw a 6% decrease in the number of self-extubations.It is important to note, however, that restraints can worsen agitation or delirium and increase the risk for self-extubation.It is likely that the reduction in self-extubation was due to an increase in sedation, which ranged from 39% to 77% during the four years. 10The head-up position, with the bed elevated at 30 degrees, increases the risk for self-extubation by allowing the patient's hands to be in closer to the endotracheal tube.While this position may help prevent aspiration, it also promotes self-extubation and should be limited in some patients. 2e lack of an appropriate sedation level is the most common factor contributing to self-extubation in the ICU.Achieving optimal sedation can be difficult, as titration of appropriate sedation depends on both the hemodynamic and neurological status of the patient and differs from patient to patient.The goal is for the patient to tolerate the endotracheal tube, while at the same time maintaining consciousness.Patients with low sedation levels have a higher incidence of self-extubation, possibly explained by a lack of tolerance for the endotracheal tube and increased ventilator-patient asynchrony. 1 Use of the Modified Ramsay Sedation Scale protocol has been shown to decrease self-extubation from 7% to 3% within one year due to appropriate management of patient agitation. 11However, it is equally important to avoid over sedation in mechanically ventilated patients, since this has been associated with prolonged mechanical ventilation, increased ICU length of stay, and an increased incidence of nosocomial infection. 3Use of a nurse-driven sedation protocol can help prevent over sedation and significantly reduce the frequency of self-extubation.
Nursing compliance with a weaning protocol also lowers the risk of self-extubation in medical ICU patients.In Jarachovic's study, 82% of patients who self-extubated were not on a weaning protocol; this demonstrates the need for a standardized weaning protocol. 12Weaning protocols reduce the overall duration of mechanical ventilation, re-intubation rates, and nosocomial infections. 3e Self-Extubation Risk Assessment Tool (SERAT) was developed to identify patients at a high risk for self-extubation (Figure 1).It is based on the Bloomsbury Sedation Score (which is similar to the Richmond agitation scale) and the Glasgow Coma Scale and has 100% sensitivity and 79% specificity in identifying patients at risk for self-extubation. 3The SERAT tool predicts the risk for self-extubation with the highest accuracy when the Bloomsbury Sedation Score-Glasgow Coma Scale scores fall within the dark grey zone (top right zone).The risk for self-extubation can be predicted with the highest sensitivity when the scores falls within the light grey zone (middle zone). 13his tool indicates that higher Glasgow Coma scale scores and lower sedation scores both influence the risk for self-extubation.Patients identified by this tool as at risk should be monitored more closely by nursing personnel to prevent self-extubation.

icu quality imPrOvement
Monitoring self-extubation rates in ICUs provides a good ICU care monitoring tool.An increased number of self-extubations requiring re-intubation indicates a need to review nursing and sedation protocols.An increased number of self-extubations not requiring re-intubation indicates a need to review weaning protocols.Tracking the number per month provides a trend that might lead to a root-cause analysis if the number goes up.

Key POints
1.The most common risk factor for self-extubation is inadequate sedation that leads to patient agitation.Optimal sedation can be difficult to achieve, but the use of sedation protocols can reduce self-extubation rates.
2. Self-extubation is more common in surgical patients, who account for 58.9% of all self-extubation cases. 1 These patients should be monitored closely by experienced nurses who can help decrease the rate of self-extubation.
3. Self-extubations often occur in patients scheduled for elective extubation within a few hours, suggesting that health care personnel need to better manage weaning and extubation timing.
4. The frequency of self-extubation is higher during the hour before and after nursing shift changes, and this factor was relevant in almost 50% of selfextubations in a tertiary care ICU over a one year period. 1 Adopting a practice of increased patient surveillance during shift changes could help significantly decrease the incidence of self-extubation.