Magnesium infusion for refractory non-surgical pheochromocytoma crisis

Chelsea K Krueger PharmD, Kimberly A Turner MPAS, PA-C, Raymond A Moreno AG-ACNP, Biosha B Jones, Olakunle Idowu MD


Pheochromocytoma crisis is a rare medical emergency characterized by severe hypertension, shock, and multiorgan failure. Despite its widespread availability, low cost, and wide therapeutic index, magnesium sulfate has been utilized primarily as an adrenergic antagonist during pheochromocytoma resection. This case report describes a 57-year-old man with recurrent nonsurgical pheochromocytoma crisis refractory to adrenergic antagonism. Initiation of a magnesium sulfate continuous infusion provided rapid hemodynamic control in the setting of inoperable disease. This case highlights the role and dosing of magnesium sulfate in the management of pheochromocytoma crisis.

Keywords: Pheochromocytoma, magnesium sulfate, hypertension, hemodynamics, adrenal gland neoplasm

Article citation: Krueger CK, Turner KA, Moreno RA, Jones BB, Idowu O. The Southwest Respiratory and Critical Care Chronicles 2019; 7(30):47–50
From: University of Texas MD Anderson Cancer Center Division of Pharmacy (CKK); Texas Tech University Health Sciences Center School of Pharmacy (CKK); University of Texas MD Anderson Cancer Center Department of Critical Care (KAT, RAM, BBJ, OI).
Submitted: 2/23/2019
Accepted: 4/30/2019
Reviewer: Camilo Pena MD
Conflicts of interest: none
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