Crossover design

Shengping Yang PhD, Gilbert Berdine, MD


I am planning a clinical trial to compare two diets on reducing the risk of type II diabetes. Because there is a restriction on the total budget, I would prefer to enroll a small number of participants. Meanwhile, it is important that there is sufficient statistical power to detect a clinically meaningful difference. Is there any study design that can be utilized?

Keywords: crossover design, carryover effect, sample size

Article citation: Yang S, Berdine G. Crossover design. The Southwest Respiratory and Critical Care Chronicles 2019;7(30):63–66
From: Department of Biostatistics (SY), Pennington Biomedical Research Center, Baton Rouge, LA; Department of Internal Medicine (GB), Texas Tech University Health Sciences Center, Lubbock, Texas
Submitted: 7/2/2019
Conflicts of interest: none
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