Immunoglobulin E associated systemic conditions

Amr Ismail MD, Kenneth C. Iwuji MD, James A. Tarbox MD


Immunoglobulin E (IgE) was the last immunoglobulin to be discovered, possibly secondary to its low levels in plasma. Following extensive investigation, its role in the pathogenesis of several diseases, most notably atopic conditions, has become evident. The immunologic pathways related to its synthesis and relation to effector cells is becoming more lucid. This has allowed for the emergence of new medications that target different steps in its activity. In this review, we will summarize some of the most common systemic pathologies in which IgE has a role in their etiology.

Keywords: Immunoglobulin E, Eosinophilic granulomatosis with polyangiitis, Churg Strauss syndrome, drug hypersensitivity, anaphylaxis, hyper IgE syndrome

Article citation: Ismail A, Iwuji KC, Tarbox JA. Immunoglobulin E associated systemic conditions. The Southwest Respiratory and Critical Care Chronicles 2019;7(30):29–35
From: Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas
Submitted: 5/31/2019
Accepted: 7/5/2019
Reviewer: John Pixley MD
Conflicts of interest: none
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Editor’s note: This review was revised on 9/20/2019