Shazma Khan BSA, Crystal Ike BS, Jeff Dennis PhD, Kenneth Nugent MD
The Centers for Disease Control and Prevention reported 8,916 cases of tuberculosis in 2019. Reducing the number of cases of active tuberculosis requires identification of patients with latent tuberculous infections (LTBI). Optimal screening for LTBI requires information about the demographics and characteristics of people who are more likely to have had tuberculous infection. Information from the 2011–2012 National Health and Nutrition Examination Survey (NHANES) was used to determine the number and characteristics of adults from a representative sample of the United States who had LTBI. Latent tuberculous infection was identified either by a positive skin test or by a positive QuantiFERON blood test. Information about the number of patients with active tuberculosis in Texas was determined from reports from the Texas State Department of Health Services. The NHANES database for the years 2011–2012 included 5,684 adults. Participants with a positive QuantiFERON blood test were more likely in the age group 45–64, male, foreign born, and have less than a high school education. Participants with a positive skin test had similar characteristics. Participants who had both a positive skin test and positive QuantiFERON test were more likely to be in the age group 45–64, males, foreign born, and Hispanic. In addition, they had diabetes, self-reported fair/poor health, and an educational level less than high school. In the State of Texas tuberculosis occurred more frequently in individuals older than 75 who were male and were not US born Texas residents. Important clinical diagnoses included diabetes, alcohol abuse, correctional facility residence, non-injection drug use, positive HIV status, and homelessness. Information from the NHANES study and from the State Department of Health Services in Texas provides information needed to develop screening programs for latent tuberculosis and active tuberculosis.
Keywords: Latent tuberculous infection, skin test, QuantiFERON test, risk factors, NHANES
Article citation: Khan S, Ike C, Dennis J, Nugent K. The prevalence and characteristics of adults with latent tuberculous infection in the United States and the implications for healthcare in Texas. The Southwest Respiratory and Critical Care Chronicles 2021;9(39):53–62
From: School of Medicine (SK, CI), Department of Public Health (JD), Department of Internal Medicine (KN), Texas Tech University Health Sciences Center, Lubbock, Texas
Submitted: 3/1/2021
Accepted: 4/4/2021
Reviewer: Jacob Nichols MD
Conflicts of interest: none
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