Clinical studies with high flow nasal cannula oxygen delivery in 2015
HFNC devices can provide humidified oxygen at high flow rates with high FiO2s. This method of oxygen delivery appears to be more comfortable than using noninvasive ventilation, and it does improve oxygenation, reduce respiratory rates, and reduce the sense of dyspnea. This modality has been studied most in patients with acute hypoxemic respiratory failure. The study reported by Frat et al provides good evidence that patients with moderate to severe respiratory failure (PaO2/FiO2 < 200) may benefit the most.
The more complex the patient’s underlying medical problems are the more likely HFNC therapy to fail
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