Pneumomediastinum secondary to invasive and non-invasive mechanical ventilation
Abstract
Pneumomediastinum (PM) is defined as the presence of abnormal gas in the mediastinum. It is a known complication of invasive mechanical ventilation and has been reported with non-invasive ventilation. Recent studies have reported that the incidence of barotrauma is lowest in post-operative patients and is highest in mechanically ventilated patients with acute respiratory distress syndrome. The incidence has dropped with the low tidal volume ventilation technique. Chest x-rays can miss up to 25% of small PMs detected by computed tomography scans of the chest. Pneumomediastinum is managed with low tidal volume ventilation with plateau pressures <30 cm H2O and treatment of the underlying lung disease. Novel ways of ventilation, such as high frequency oscillatory ventilation and asynchronous independent lung ventilation, may improve ventilation in some patients.
Keywords: Pneumomediastinum, barotrauma, mechanical ventilation, air leak, ventilator induced lung injury
Downloads
References
Gasser CR, Pellaton R, Rochat CP. Pediatric spontaneous
pneumomediastinum: narrative literature review. Pediatric
Emergency Care 33(5):370–374.
Hoo GW. Barotrauma and mechanical ventilation. emedicine.
medscape.com/article/296625-overview. Updated: Apr 18, 2018.
Caceres M, Braud R L, Maekawa R, et al. Secondary pneumomediastinum:
A retrospective comparative analysis. Lung
Sep-Oct;187(5):341–6.
De Latorre FJ, Klamburg J J, Leon C, et al. Incidence of
pneumothorax and pneumomediastinum in patients with aspiration
pneumonia requiring ventilatory support. Chest 1977
Aug;72(2):141–4.
Pérez LA, González DM, Álvarez KM, et al. Nasal CPAP
versus mechanical ventilation in 28 to 32-week preterm
infants with early surfactant administration. Biomedica 2014
Oct-Dec;34(4):612–23.
Loza RC, Rodríguez GV, Fernández NM. Ventilator-induced
lung injury (VILI) in acute respiratory distress syndrome:
volutrauma and molecular effects. Open Respir Med J 2015
Jun 26;9:112–9.
Weng L, Huang X, Chen L, et al. Prognostic factors for
severe Pneumocystis jiroveci pneumonia of non-HIV patients
in intensive care unit: a bicentric retrospective study. BMC
Infect Dis. 2016;16(1):528.
Turlapati KM, Spear RM, Paterson BM. Mediastinal tube
placement in children with pneumomediastinum: hemodynamic
changes and description of technique. Crit Care Med
Jul;24(7):1257–60.
Boudreault F, Pinilla-Vera M, Englert JA, et al. Zinc deficiency
primes the lung for ventilator-induced injury. JCI Insight 2017
Jun 2;2(11). pii: 86507. doi: 10.1172/jci.insight.86507.
Okada M, Adachi H, Shibuya Y, et al. Diagnosis and treatment
of patients with spontaneous pneumomediastinum.
Respir Investig 2014 Jan. 52(1):36–40.
Wong KS, Wu HM, Lai SH, et al. Spontaneous pneumomediastinum:
analysis of 87 pediatric patients. Pediatr Emerg
Care 2013 Sep. 29(9):988–91.
Wu CH, Chen CM, Chen CC, et al. Esophagography after
pneumomediastinum without CT findings of esophageal perforation:
is it necessary?. AJR Am J Roentgenol 2013 Nov.
(5):977–84.
Ho AS, Ahmed A, Huang JS, et al. Multidetector computed
tomography of spontaneous versus secondary pneumomediastinum
in 89 patients: can multidetector computed tomography
be used to reliably distinguish between the 2 entities?.
J Thorac Imaging 2012 Mar. 27(2):85–92.
Umegaki T, Kenichiro S, Akihisa N, et al. Impact of steroid medication
before hospital admission on barotrauma in mechanically
ventilated patients with acute respiratory distress syndrome
in intensive care units. J Anesth 2014 Oct;28(5):681–6.
Yang L, Li F, Li D, et al. Clinical analysis of complications after
non- invasive positive pressure ventilation and an inquiry
into the respiratory treatment strategy in patients with SARS.
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2004 May;16(5):
–3.
Zhang L, Shen M, Zhang F, et al. Survival analysis and
risk factors for mortality in connective tissue diseaseassociated
pneumomediastinum. Rheumatol Int 2014 Dec;
(12):1657–63.
Colombi D, Ehlers-Tenenbaum S, Palmowski K, et al.
Spontaneous pneumomediastinum as a potential predictor
of mortality in patients with idiopathic pulmonary fibrosis.
Respiration 2016;92(1):25–33.
Ebina M, Inoue A, Takaba A. Management of spontaneous
pneumomediastinum: Are hospitalization and prophylactic
antibiotics needed? Am J Emerg Med 2017 Aug;35(8):
–1153.
García LG, Corsino Rey, Medina A, et al. Severe subcutaneous
emphysema and pneumomediastinum secondary to
noninvasive ventilation support in status asthmaticus. Indian
J Crit Care Med 2016 Apr;20(4):242–4.
Bakhshaee M, Jokar MH, Mirfeizi Z, et al. Subcutaneous
emphysema, pneumomediastinum and pneumothorax in a
patient with dermatomyositis. Iran J Otorhinolaryngol 2017
Mar; 29(91):113–116.
Ruggeri P, Girbino G. Fatal pneumomediastinum associated
with use of noninvasive mechanical ventilation. Respirol
Case Rep 2014 Dec;2(4):126–8.
Weaver JB, Kumar AB. Tension pneumomediastinum: rare
cause of acute intraoperative circulatory collapse in the setting
of unremarkable TEE finding. J Clin Anesth 2017 Feb;
:136–138.
Colin GC, Ghaye B, Coche E Tension pneumomediastinum
secondary to thoracic air-leak syndrome in chronic graft versus
host disease. Diagn Interv Imaging 2014 Mar;95(3):317–9.
McGinley J, Corcoran T, Canny G, et al. A case of pneumomediastinum
in paediatric ARDS: to oscillate or not? Paediatr
Anaesth 2001 May;11(3):366–9.
Mehdiratta N, Archer M, Stewart M, et al. Novel airway and
ventilator management of tracheobronchial disruption after
blunt trauma. Ann Thorac Surg 2017 Nov;104(5):e359–e361.
Ali HS, Hassan IF, George S. Extra corporeal membrane oxygenation
to facilitate lung protective ventilation and prevent
ventilator-induced lung injury in severe Pneumocystis pneumonia
with pneumomediastinum: a case report and short literature
review. BMC Pulm Med 2016 Apr 14;16(1):52. doi:
1186/s12890-016-0214-4.
Paluszkiewicz P, Bartosinski J, Rajewska-Durda K, et al. Cardiac
arrest caused by tension pneumomediastinum in a Boerhaave
syndrome patient. Ann Thorac Surg 2009 Apr;87(4):
–8.