TY - JOUR AU - Jasmin Rahesh AU - Arham Siddiqui AU - Praveen Tumula AU - Rahul Chandra PY - 2022/07/22 Y2 - 2024/03/28 TI - A rare case of mixed phenotype acute leukemia: acute myeloid leukemia to early T-cell precursor acute lymphoblastic leukemia transformation JF - The Southwest Respiratory and Critical Care Chronicles JA - The Chronicles VL - 10 IS - 44 SE - Case Reports DO - 10.12746/swrccc.v10i44.967 UR - https://pulmonarychronicles.com/index.php/pulmonarychronicles/article/view/967 AB - Mixed phenotypic acute leukemia (MPAL) comprises of both lymphoid and myeloid markers or blasts in a single population. Diagnostic criteria hinges on classifications provided by identifying these lineages based on cytogenetic markers taken throughout the disease course.  We describe an interesting presentation of a patient who had first presented with Acute Myeloid leukemia (AML) but 8 weeks later transformed into Early precursor T cell ALL (ETP-ALL).  Cytogenetics were taken throughout the course of the cancer and confirmed the presence of a CD34 precursor cell marker. This transformation and cytogenic markers indicated a pluripotent progenitor cell origin confirming the diagnosis of MAPL. This case highlights a pluripotent progenitor origin with initial presentation as AML (myeloid clone) and later as ALL after initial partial response to AML therapy due to clonal evolution.  ER -