Addison's disease in pregnancy

Abstract

Addison's disease presents a unique challenge when it occurs during pregnancy due to its potential for maternal and fetal complications if left untreated. This review synthesizes present information about the pathophysiology and clinical aspects of Addison's disease during pregnancy using information from case reports. Pregnancy-induced physiological changes can complicate the diagnosis of adrenal insufficiency as clinical symptoms of the disease overlap with typical pregnancy symptoms; a high index of suspicion is therefore necessary. Diagnostic tests include short synacthen tests and measurement of serum electrolytes, adrenocorticotropic hormone levels, and cortisol levels. Adequate hormone supplementation is crucial for ensuring maternal and fetal well-being. Pregnancy and Addison's disease can have favorable outcomes with proper management, highlighting the importance of early diagnosis and treatment.